Spero Therapeutics is trading 5.2% lower at $1.29, with the decline appearing consistent with profit-taking after the prior session’s 19.30% gain.

  • It opened September 23, 2026, below the previous session’s $1.36 close.
  • No new company-specific announcement has been identified. Broader U.S. equities are weaker, with the Nasdaq down 0.80%, while biotechnology is comparatively stronger, with XBI up 2.07%.